Abstract
Medium-chain triglyceride (MCT), a fat consisting almost exclusively of triglycerides of C 8 and C 10 fatty acids, has been used as a vehicle for cholesterol in experiments involving the establishment of experimental atheromata in rabbits; and the results compared with those of similar experiments in which corn oil, coconut oil, or tristearin was the cholesterol vehicle. Coconut oil was significantly more atherogenic than was corn oil. MCT and tristearin were less cholesteremic than was corn oil but equally atherogenic. When the atherogenicity of the various fats was expressed as a function of the hypercholesteremia they induced, MCT, tristearin, and coconut oil were all more atherogenic than corn oil. When MCT, tristearin, coconut oil, and corn oil were fed to rabbits with pre-established atheromatous lesions, significant exacerbation of the severity of lesions was observed in every case, but the lesions in the aortic arch of the corn oil-fed group were significantly less severe than those observed in the other dietary groups.
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