Abstract
Each defined species of active oxygen implicated in oxygen biochemistry, with the exception of superoxide (· O2 -, HOO ·), is known to oxidize cholesterol under conditions potentially present in vivo. Oxysterols found in tissues thus may have at least two origins, enzymic ones related to in vivo metabolism (including lipid peroxidation) and nonenzymic origins in which active oxygen species hydroxyl radical (HO), dioxygen cation (O2 +) singlet dioxygen (1O2), ground state dioxygen (3O2), peroxide (O2 2-, HOO-, H2O2) ozone (O3), and as yet unrecognized species may be implicated. As the oxysterols formed in all cases have demonstrated biological activities in a variety of bioassays, the question must be posed whether such oxysterols, if formed in. vivo and not properly controlled by protective metabolism, are a threat to human health.KeywordsSteryl EsterCumene HydroperoxideCarbonyl OxideCholesterol OxideCarbon Nuclear Magnetic ResonanceThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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