Abstract
This study indicates that cholecystokinin (CCK-8S) and high-frequency afferent stimulation (HFS) modify neuronal responses to stimulation of the perforant pathway in hippocampal field CA1. HFS, previously neutral with regard to modifications, induced depression of both field evoked action potentials (EAPs) and field excitatory postsynaptic potentials (EPSPs) in the presence of 500 nM CCK-8S. However, in the presence of 1 µM CCK-8S, HFS induced a potentiation of both field evoked responses. With intermediate concentrations of CCK-8S, HFS was indifferent to potentiation or depression: 750 nM CCK-8S was not associated with modifications, whereas only potentiation of EAPs occurred with 900 nM CCK-8S. The mechanism underlying HFS/CCK-8S-induced LTP or LTD may involve reduction of γ-aminobutyric acid (GABA) release. LTP and LTD may underlie certain forms of memory, and this study implicates hippocampal CCK-8S/GABAergic pathways in their induction.
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