Abstract
Cholestasis is associated with an accumulation of endogenous opioids in plasma which are known to reduce erythrocyte deformability in-vitro. We compared chlorpromazine-induced erythrocyte shape change in bile duct ligated (cholestatic), sham-operated and control rats to evaluate the effect of cholestasis on erythrocyte deformability. Cell shape change was measured using a polarized light scattering method. Cholestasis reduced erythrocyte shape change induced by chlorpromazine and the decrease in erythrocyte deformability correlated with the duration of cholestasis. Doses of chlorpromazine which produced 50% effect on erythrocyte shape change in cholestatic groups were significantly (P < 0.001) higher than controls. Erythrocyte osmotic fragility was also measured. Cholestasis produced increased resistance to osmotic shock in erythrocytes. Erythrocyte shape change is reduced in cholestasis probably due to the accumulation of endogenous opioids in plasma.
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