Abstract
Thirteen allergic adolescent subjects without clinical asthma but with exercise-induced bronchoconstriction participated in this study. In a double-blind protocol, they were given placebo, 4 mg, or 12 mg chlorpheniramine at bedtime the evening before exposure to 1 ppm sulfur dioxide (SO2) during moderate exercise. Pulmonary function (forced expiratory volume in 1 second and total respiratory resistance) and nasal work of breathing were measured before and after exposure. Chlorpheniramine did not alter the statistically significant changes in pulmonary function seen after SO2 exposure. However, 12 mg chlorpheniramine did block the SO2-induced increase in the nasal work of breathing. It is concluded that treatment with an H1 blocking antihistamine does not affect the mechanisms underlying SO2-induced bronchoconstriction, although it does inhibit SO2-induced nasal function changes.
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