Abstract
CHLOROQUINE PHOSPHATE was introduced in 1946 as a more effective, convenient, and less toxic agent than existing drugs for the suppression and treatment of malaria; it soon replaced other drugs used for this purpose. In the years since its introduction numerous articles have appeared advocating the use of chloroquine in the treatment of various other diseases including lupus erythematosus, arthritis, amebiasis, infectious mononucleosis, and even rafractory epilepsy. While the literature contains numerous articles describing the undesirable side-effects when chloroquine is used in prolonged therapeutic dosage, there has been a paucity of reports regarding acute poisoning from overdosage of the drug. In 1961 Cann and Verhulst 1 reporting from the files of the National Clearinghouse for Poison Control Centers of the US Department of Health, Education and Welfare, described four cases of acute poisoning in children resulting from the ingestion of chloroquine phosphate; of these cases, three resulted in death. (The
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