Abstract
The long-term health effects of chloral hydrate are discussed and its carcinogenicity in mice are reported from the University of California, Davis, and the California School of Public Health, Berkeley.
Highlights
Chloral hydrate is a metabolite of trichloroethylene, a known carcinogen
PRESENTING SIGNS OF MITOCHONDRIAL DISEASE Clinical features of 51 patients confirmed with mitochondrial respiratory chain disease and clinical investigations most helpful in diagnosis of different phenotypes are reported from the Divisions of Clinical Neuroscience and Neurobiology, University of Newcastle upon Tyne, UK
Features other than ptosis and ophthalmoplegia identified as clues to respiratory chain dysfunction were as follows: 1) lactic acidosis with deafness, short stature/failure to thrive, or basal ganglia calcifications on CT; 2) familyhistory of neurological disease with maternal transmission; and 3) proximal myopathy and CNS disease
Summary
PRESENTING SIGNS OF MITOCHONDRIAL DISEASE Clinical features of 51 patients confirmed with mitochondrial respiratory chain disease and clinical investigations most helpful in diagnosis of different phenotypes are reported from the Divisions of Clinical Neuroscience and Neurobiology, University of Newcastle upon Tyne, UK. Many of us who have stocked chloral hydrate in large quantities for use in sedating children for EEGs and other short procedures may want to reconsider its safety and substitute an alternative. Its chronic long-term use as a sedative in mentally retarded children should be discouraged until further studies are completed.
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