Vaccines | VOL. 10

Chitosan-Based Nanomaterial as Immune Adjuvant and Delivery Carrier for Vaccines

Publication Date Nov 11, 2022


With the support of modern biotechnology, vaccine technology continues to iterate. The safety and efficacy of vaccines are some of the most important areas of development in the field. As a natural substance, chitosan is widely used in numerous fields—such as immune stimulation, drug delivery, wound healing, and antibacterial procedures—due to its good biocompatibility, low toxicity, biodegradability, and adhesion. Chitosan-based nanoparticles (NPs) have attracted extensive attention with respect to vaccine adjuvants and delivery systems due to their excellent properties, which can effectively enhance immune responses. Here, we list the classifications and mechanisms of action of vaccine adjuvants. At the same time, the preparation methods of chitosan, its NPs, and their mechanism of action in the delivery system are introduced. The extensive applications of chitosan and its NPs in protein vaccines and nucleic acid vaccines are also introduced. This paper reviewed the latest research progress of chitosan-based NPs in vaccine adjuvant and drug delivery systems.


Vaccine Adjuvants Nucleic Acid Vaccines Chitosan-based Nanoparticles Immune Delivery Delivery Systems Efficacy Of Vaccines Protein Vaccines Nanoparticles Adjuvant Delivery Systems Immune Stimulation

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