Abstract
Chitosan aerogels with potential applications as effective local hemostatic agents were prepared using supercritical carbon dioxide drying to preserve the chitosan network structure featuring high internal surfaces and porosities of up to 300 m²/g and 98%, respectively. For the first time, hemostatic efficacy of chitosan-based aerogel particles was studied in vivo on a model of damage of a large vessel in the deep wound. Pigs were used as test animals. It was shown that primary hemostasis was achieved, there were no signs of rebleeding and aerogel particles were tightly fixed to the walls of the wound canal. A dense clot was formed inside the wound (at the femoral artery), which indicates stable hemostasis. This study demonstrated that chitosan-based aerogel particles have a high sorption capacity and are highly effective as local hemostatic agents which can be used to stop massive bleeding.
Highlights
According to statistics from the World Health Organization, the main cause of death in injuries is a large amount of blood loss
Sample 1 refers to aerogel particles obtained from chitosan with a molecular weight of 111 kD; sample 2 is aerogel particles obtained from chitosan with a molecular weight of 125 kD; sample 3 is aerogel particles obtained from chitosan with a weight of 294 kD; sample 4 is aerogel particles obtained from chitosan with
There were no signs of rebleeding, which indicates the effectiveness of the use of chitosan-based aerogel particles
Summary
According to statistics from the World Health Organization, the main cause of death in injuries is a large amount of blood loss. The development of new functional materials for the creation of highly effective local hemostatic agents is an urgent task for modern science. Aerogels based on various biopolymers that have such properties as large specific surface area, high porosity and sorption capacity, low density and biological compatibility with human tissues and organs [1,2]. Chitosan biopolymer is a natural polysaccharide that is completely safe for humans; it has antimicrobial activity and is able to absorb biological fluids, including blood [3,4]. Chitosan macromolecules consist of randomly bound β-(1-4)-D-glucoseamine units and.
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