Abstract
A series of chiral bifunctional phosphinothioureas were synthesized and applied to the enantioselective Morita–Baylis–Hillman reaction of aromatic aldehydes with acrylates. In the presence of 8mol% of organocatalyst 2e, the Baylis–Hillman adducts were obtained in good enantioselectivities and up to 96% yield under mild reaction conditions.
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