Abstract

A catalytic amount of a chiral Brønsted acid with aqueous H2O2 as the oxidant is sufficient for the enantioselective Baeyer–Villiger oxidation of 3-substituted cyclobutanones to give the corresponding γ-lactones in excellent yields and up to 93 % ee. The method employs benign aqueous H2O2 instead of stoichiometric amounts of a dangerous peracid.

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