Abstract
Letters17 August 2004Chest Pain Relief by NitroglycerinArthur T. Evans, MD, MPH and Brendan M. Reilly, MDArthur T. Evans, MD, MPHFrom Cook County Hospital and Rush Medical College, Chicago, IL 60612.Search for more papers by this author and Brendan M. Reilly, MDFrom Cook County Hospital and Rush Medical College, Chicago, IL 60612.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-4-200408170-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Henrikson and colleagues (1) concluded that pain relief by nitroglycerin did not predict disease in 459 patients admitted to the hospital for work-up of possible ischemic heart disease. Many study participants with missing or uninterpretable test results were dropped from the analysis, an important type of selection bias that can be measured (and eliminated) when calculating likelihood ratios (2). In addition, the study involved a highly select subgroup—patients with rest pain occurring during evaluation—rather than all patients presenting with chest pain. However, the most serious threat to the validity and generalizability of Henrikson and colleagues' findings is ...
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