Abstract
A quick and reliable method for the evaluation and classification of two types of tissues is presented. Several chemometric methods were applied to evaluate multivariate data of the tissue samples with respect to the content of trace elements. The content of Pb, Al, Zn, Cd, Cu, Ni and Co was determined in samples of healthy and cancerous tissue obtained from 26 patients. Determination was done at milligram/kilogram level with inductively coupled plasma optical emission spectrometry (ICP-OES) and atomic absorption spectroscopy (AAS) techniques. Contents of trace metals in studied tissues are not normally distributed; however, normal distribution was confirmed for log values. There is a statistically significant difference in the content of Zn, Cd, Cu and Al (p < 0.01) and Ni and Co (p < 0.05) when healthy tissue is compared to cancerous one. Correlation between contents of trace elements for studied tissues was positive; the highest was found between Zn and Cu. A chemometric methodology seems to be a promising tool for classifications of the tissue samples.
Highlights
The human body is a very complex structure and an appropriate concentration of trace elements is very important for its optimal operation
Trace elements are necessary to preserve a general body homeostasis, recent studies suggest that the excessive exposure to some of them may act as pathogenic factors
A parametric analysis of variance (ANOVA) test was performed in order to find any differences in the content of studied elements between the two types of tissue
Summary
The human body is a very complex structure and an appropriate concentration of trace elements (the contents of which is less than 0.01 % of total body weight) is very important for its optimal operation. The results of determinations of trace elements content for both types of tissue were analysed statistically [21,22,23]. We have compared data from two sets— concentration of trace elements in tissues classified as cancerous and in the one supposed to be healthy.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
