Abstract
Acidified solvents are commonly used in reversed-phase liquid chromatography (RPLC) to adjust mobile-phase pH and the ionization state of ionogenic compounds. When methanol-containing solvents are acidified with formic or trifluoroacetic acids, esters can be formed at chromatographically relevant rates, affecting baseline quality, retention, and selectivity. Understanding these effects is the first step toward avoiding the problems that can be caused by esterification in the bottle.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
