Chemische konstitution und mutagene wirkung V. Vergleichende untersuchung der wirkung von äthyleniminen auf menschliche leukozyten chromosomen

Abstract

Three chemically related ethyleneimine compounds were tested on human leukocyte chromosomes in the following molar concentrations: (1) 2-ethyleneimino-5,6,7,8-tetradronaphthoquinone-1,4 (A137), monofunctional, 1·10 −6; (2) 2,5-bis-(ethyleneimino)- p-benzoquinone (Chinon I), bifunctional, 1/2·10 −6; and (3) 2,3,5-tri-(ethyleneimino)- p-benzoquinone (Trenimon), trifunctional, 1/3·10 −6. Thus the number of active groups was the same in each blood culture. Achromatic lesions (AL), chromatid breaks (B′), isochromatid breaks (B″), and chromatid translocations (RB′) were induced. Their frequencies were lowest with A137, intermediary with Chinon I, and highest with Trenimon. The findings are interpreted as being a result of cross-linking reactions.