Abstract
A variety of polysubstituted δ-lactones containing three or four stereocenters were prepared from various dialkyl 2-(3-oxo-1,3-diarylpropyl)malonates by a Barbier-type zinc-mediated allylation or cyclohexenylation of the keto group, followed by intramolecular lactonization/transesterification. The stereochemistry of the major isomers was confirmed by X-ray crystal structure analysis of representative compounds.
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