Abstract
Based on a mechanistic understanding of asymmetric cyanohydrin synthesis catalyzed by chiral titanium−salen complexes, a new catalyst based on vanadium(IV) has been developed. The chiral (salen)VO catalyst is more enantioselective than the titanium-based systems, 0.1 mol % of the catalyst being sufficient to convert aromatic and aliphatic aldehydes into the corresponding trimethylsilyl ethers of cyanohydrins with 68−95% enantiomeric excess at room temperature.
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