Abstract
The first stereoselective total synthesis of synparvolide C has been accomplished. An acid-catalyzed epoxide ring-opening reaction and ring-closing metathesis (RCM) were used for the cyclic ether and δ-lactone formation, respectively, to furnish the core structure of the target molecule. These reactions along with a succession of functional group manipulations led to the preparation of the natural product. The spectral and analytical data were used to establish the absolute configuration.
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