Abstract
We herein, report the first total synthesis of Dermacozine A and B in moderate to high yields from a commercially available methyl 2-bromo (or chloro)-3-nitrobenzoate in an atom efficient route. The key carbon–nitrogen and carbon-carbon bond forming reactions involve inter and intra-molecular Pd (0) catalyzed N-arylations and regioselective Friedel-Crafts benzoylation respectively. Nitrile group was used as a masked carboxylic group to differentially functionalize two carboxylic acids to achieve Dermacozine C.
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