Abstract
Spirooxindoles are important compounds as they are often found in bioactive molecules. Thus, the development of new spirooxindoles and of synthetic routes to spirooxindoles is a great interest to discover new biofunctional molecules and therapeutic leads. We developed a concise method for the synthesis of spirooxindoles bearing a furanose unit. 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU) was used for an aldol reaction of a pyruvic aldehyde derivative with isatin; reduction of the ketone group was followed by treatment with acid to generate the spirofuranose unit. A set of furanose spirooxindoles were obtained in good to high yields.
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