Abstract
4-Aryl-6-(trifluoromethyl)-2-pyrones reacted with the nonstabilized azomethine ylide obtained from sarcosine and formaldehyde under reflux in benzene for 6 h, resulting in [3+2] cycloaddition that gave 4-aryl-6-methyl-7a-(trifluoromethyl)-2,4a,5,6,7,7a-hexahydropyrano-[2,3-c]pyrrol-2-ones in 42–56% yields. In the case of 4-aryl-3-carbethoxy-6-(trifluoromethyl)-2-pyrones, besides the respective pyrano-[2,3-c]pyrrolidines (66–71% yields) also 4-aryl-1-methyl-2-(trifluoromethyl)pyrroles were isolated as minor products.
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