Abstract
The rapid synthesis of 2,4- and 2,5-disubstituted oxazoles via metal-catalyzed cross-coupling reactions is reported. The 4- or 5-position of the corresponding 4- or 5-halogenated 2-butylthiooxazoles was successfully functionalized via Suzuki― Miyaura, Sonogashira and Stille cross-coupling reactions. The 2-position of the 2-butylthiooxazoles obtained was further coupled to various organozinc reagents through palladium- or nickel-mediated cross-coupling reactions.
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