Abstract
New Cypridina luciferin analogues, 6-(4-methoxyphenyl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one (MCLA) and 2-methyl-6-(2-naphthyl)imidazo[1,2-a]pyrazin-3(7H)-one (NCLA), were prepared together with their oxyluciferin analogues, 2-acetamido-5-(4-methoxyphenyl)pyrazine (MCOLA) and 2-acetamido-5-(2-naphthyl)pyrazine (NCOLA). Various chemiluminescence properties of these compounds were compared with those of known luciferin analogues, 2-methyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one (CLA) and 6-(3-indolyl)-2-methylimidazo[1,2-a]pyrazin-3(7H)-one (ICLA). The light yields obtained from ICLA, MCLA, and NCLA were much higher than CLA in diethylene glycol dimethyl ether (diglyme), in which triplet oxygen was the oxidant. In aqueous solution, employing superoxide ion as the oxidant, NCLA emitted light weaker than CLA and MCLA. ICLA gave almost no light on account of no fluorescence intensity of the emitter (oxyluciferin analogue ICOLA) in aqueous solution. For applications to the detection of active oxygen species p...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
