Abstract
Bifunctional α-amino nitriles are not only versatile intermediates in organic synthesis but also exhibit a valuable dual reactivity, which has been utilized in a broad range of synthetic applications. This review highlights recent developments in the chemistry of α-amino nitriles, including asymmetric synthesis of α-amino acids via Strecker reactions using chiral auxiliaries and catalysts, α-amino nitriles as masked iminium ion equivalents in cationic reactions and the synthesis of natural products and heterocycles, and α-metallation to provide nucleophilic acyl anion equivalents and applications to asymmetric Umpolung reactions.
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