Abstract
Abstract Reaction of 2 with bis(tributyltin) in the presence of 3 mol % Pd 2 (dba) 3 , 6 mol % XPhos, and 30 equiv of LiBr in wet and air bubbled THF at reflux for 8 h afforded the desired products 3 in 73–74% yields. The cross-coupling reaction of 3a with aryl iodides in the presence of 10 mol % Pd(PPh 3 ) 4 and 10 mol % CuI afforded the coupled products 4a – p in 47–90% yields. The coupling reaction of 3b with various alkynyl bromides having aryl-, alkyl, or trialkylsilyl group also afforded the corresponding 1,3-enynes 5a – g in 61–77% yields.
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