Abstract
C-alkylation of phenolic acridones with 1,4-dibromo-2-methyl-2-butene under different conditions was studied. Condensations with 1,3 dihydroxy-10-methyl-acridin-9(10H)-one gave an O-alkylated product together with rutacridone and isorutacridone through C-alkylation. The aluminiumoxide and the ion exchange resin method offered the best yields for rutacridone and isorutacridone, respectively. Attempts with 4-hydroxy-10-methylacridin-9(10H)-one yielded several O-alkylated products including a dimer.
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