Abstract
Abstract A new unusual bis-tetrahydroxanthone connected through an ether bond, named asperdichrome ( 1 ), was isolated from a culture broth of Aspergillus sp. TPU1343 together with two known dimeric polyketides, secalonic acids D ( 2 ) and F ( 3 ). The fungus was isolated from a freshwater sample in Okinawa, Japan. The structure of 1 was elucidated on the basis of its spectroscopic data and comparisons were made with related compounds. Compounds 1 and 3 (heterodimers) inhibited the activity of protein tyrosine phosphatase 1B (PTP1B) with IC 50 values of 6.0 and 9.6 μM, respectively. Compound 2 (homodimer) showed reduced activity against PTP1B (40% inhibition at 15.7 μM). This is the first study on the inhibitory activities of tetrahydroxanthones against PTP1B.
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