Abstract
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Highlights
The topics of the published articles cover a wide range, which include the study of DNA adducts, DNA polymerase, DNA repair and repair defects, nanoparticle-induced DNA damage and cell death, metal toxicity, apoptosis, risk of melanoma, chemoprevention, radiosensitizer for primary culture tumor cells, signaling of a tumor suppressor gene, and adjuvant for chemotherapy
In another DNA repair related article, Kakehashi et al investigated the role of deficiency of 8-oxoguanine glycosylase 1 (Ogg1), which repairs the 8-oxo-7,8-dihydro-2 -deoxyguanosine (8-oxodGuo) residues in DNA, using the multiorgan carcinogenesis bioassay in mice [4]
Boldinova et al wrote a review on PrimPol, a human DNA polymerase with primase activity, which is involved in DNA damage tolerance, prevention of genome instability, and mitochondrial
Summary
The topics of the published articles cover a wide range, which include the study of DNA adducts, DNA polymerase, DNA repair and repair defects, nanoparticle-induced DNA damage and cell death, metal toxicity, apoptosis, risk of melanoma, chemoprevention, radiosensitizer for primary culture tumor cells, signaling of a tumor suppressor gene, and adjuvant for chemotherapy. They focused on the differential regulation of DNA repair pathways, triggered by various ENMs. The factors that dictate aberrant repair processes, including intracellular signaling, spatial interactions, and ENM-specific responses, were discussed. The oxidative DNA damage reached a steady-state following treatment with 60 μg/mL Fe3O4-NPs. Adduct formation increased after magnetic hyperthermia, with the highest amounts of oxidative lesions generated after a 40-min exposure to AMF.
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