Abstract
Microbes have amazing chemical capabilities, performing chemical reactions unprecedented in organic synthesis and producing complex, biologically active molecules not easily accessed via any other means. My lab is discovering new enzymatic transformations by studying the biosynthesis of secondary metabolites with atypical structures or chemical functionality. Our approach to pathway discovery and characterization takes advantage of the increasing availability of bacterial genome sequencing data. This talk will discuss our recent progress towards deciphering the enzymatic chemistry that mediates unusual C-C and C-N bond forming reactions in multiple natural product biosynthetic pathways. Functional and mechanistic characterization of these enzymes is revealing new chemical reactivity with potential applications in biocatalysis and metabolic engineering.
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