Abstract
This study investigates updated information in different search engines on the distribution, phytochemistry, pharmacology, and toxicology of Brugmansia suaveolens (Solanaceae) using the extracts or chemical compounds at present. This plant has been used in traditional medicine in different cultures as a hallucinatory, analgesic, aphrodisiac, nematicide, sleep inducer, and muscle relaxant, as well as a treatment for rheumatism, asthma, and inflammation. The flowers, fruits, stems, and roots of the plant are used, and different chemical compounds have been identified, such as alkaloids, volatile compounds (mainly terpenes), coumarins, flavonoids, steroids, and hydrocarbons. The concentration of the different compounds varies according to the biotic and abiotic factors to which the plant is exposed. The toxic effect of the plant is mainly attributed to atropine and scopolamine, their averages in the flowers are 0.79 ± 0.03 and 0.72 ± 0.05 mg/g of dry plant, respectively. Pharmacological studies have shown that an aqueous extract exhibits the antinociceptive effect, at doses of 100 and 300 mg/kg i.p. in mice. On the other hand, the ethanolic extract at 1000 mg/L, showed a nematocidal activity in vitro of 64% against Meloidogyne incognita in 72 h. Likewise, it showed a 100% larvicidal activity at 12.5 mg/L against Ancylostoma spp. In another study, the lethal activity of shrimp in brine from an ethanolic extract showed an LC50 of 106 µg/mL at double serial concentrations of 1000–0 (µg/mL). Although there are pharmacological and phytochemical studies in the plant, they are still scarce, which has potential for the examination of the biological activity of the more than one hundred compounds that have been reported, many of which have not been evaluated.
Highlights
Brugmansia suaveolens (Humb. and Bonpl. ex Willd.) Bercht. and J.Presl is widely distributed in the world both as a spontaneous species and as an ornamental plant [1], mainly in areas with climates ranging from tropical and subtropical to temperate [2]
It belongs to the Solanaceae family, and according to The Plant List, 12 are recognized in this genus, including hybrids and a subspecies (Brugmansia arborea, B. × candida, B. × cubensis, B. × dolichocarpa, B. × insignis, B. longifolia, B. pittieri, B. × rubella, B. sanguinea, B. sanguinea subsp. vulcanicola, B. suaveolens, and B. versicolor) [1]
Plants 2020, 9, 1161 of this review is to present complete and updated information on the current research regarding the distribution, phytochemistry, pharmacology, and toxicology of B. suaveolens, in order to identify its therapeutic potential and open new research opportunities
Summary
Brugmansia suaveolens (Humb. and Bonpl. ex Willd.) Bercht. and J.Presl is widely distributed in the world both as a spontaneous species and as an ornamental plant [1], mainly in areas with climates ranging from tropical and subtropical to temperate [2]. J.Presl is widely distributed in the world both as a spontaneous species and as an ornamental plant [1], mainly in areas with climates ranging from tropical and subtropical to temperate [2]. It belongs to the Solanaceae family, and according to The Plant List, 12 are recognized in this genus, including hybrids and a subspecies Albidoflava (Lem.) Voss (synonym), Datura suaveolens var. B. suaveolens is better known by the name Angel’s Trumpet
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