Abstract
The objective of this study was to evaluate the chemical profile of extracts (aqueous and ethanol) and the essential oil of Myrocarpus frondosus Allem?o, the sensitivity of strains of Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Listeria monocytogenes, front the extracts and essential oil, by means of the microdilution method in broth, the antioxidant activity by the ABTS method, and the content of phenolic compounds present in the extracts and oil. For the preparation of extracts from plant leaves used with ethanol and water, then separated, the chemical identification of compounds was performed by high-performance liquid chromatography (CLAE-DAD) and gas chromatography coupled to mass spectrum (CG/MS). With the chemical analysis of the extracts obtained the presence of the major compound rutin, and oil major compound was found germacrene B. In the microdilution method in broth, oil and extracts showed inhibition against all the bacteria tested in the concentrations 1 mg/ml to 0.25 mg/ml, except for Staphylococcus aureus at a concentration of 0.25 mg/ml of the essential oil and trans-caryophyllene. The results of Minimum Bactericidal Concentration showed that the essential oil had bactericidal activity at a concentration of 1mg/ml for all bacteria tested and trans-caryophyllene at the same concentration only for Listeria monocytogenes. In relation to the essential oil, antioxidant activity showed higher radical reduction capacity of 40.92% and the content of phenolic compounds ethanol extract showed more 12.72%. The in vitro results support the conclusion that the essential oil is very promising both in antimicrobial action as antioxidant activity and the leaf extracts on antioxidant activity.
Highlights
Medicinal plants have the largest pharmaceutical source that exists and the use of them is as old as human life
For the preparation of extracts from plant leaves used with ethanol and water, separated, the chemical identification of compounds was performed by high-performance liquid chromatography (CLAE-DAD) and gas chromatography coupled to mass spectrum (CG/MS)
The in vitro results support the conclusion that the essential oil is very promising both in antimicrobial action as antioxidant activity and the leaf extracts on antioxidant activity
Summary
Medicinal plants have the largest pharmaceutical source that exists and the use of them is as old as human life. The plants were the main resource used in traditional medicine [1]. The use of herbal substances stands out both as a therapeutic agent as raw material for synthesis of drugs. This practice was valued by the national pharmaceutical market international and research and development of new drugs [2]-[7]. Today many scientists from different areas are using substances extracted from medicinal plants due to its high efficacy against pathogens and its use was already proven use in traditional medicine [1]. Fabri [8] describes that plants that have antibacterial activity are extremely important, given that many bacteria are resistant to the latest antibiotics
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