Abstract
Tyrosinase is the rate-limiting enzyme for melanin production in plant and mammalian cells. Upregulation of this enzyme results in hyperpigmentation disorders. In order to treat pigmentation problems, novel skin whitening compounds are extremely screened. It is found that fatty acids based on their saturation levels either increase or decrease tyrosinase enzyme activity. Thus, fatty acids and their compositions are promising candidates for the treatment of hyperpigmentation or hypopigmentation disorders. Microalgae are rich in both saturated and unsaturated fatty acids, as well. In this study, C. cohnii and S. limacinum fatty acids were evaluated as tyrosinase inhibitor candidates. Mushroom tyrosinase activity studies displayed that both extracts increase tyrosinase enzyme activity dose-dependently. On the other hand, S. limacinum at 200µgml-1 concentration almost decreased half of tyrosinase enzyme activity in B16-F10 cells. Besides, it was 3 times more efficient for tyrosinase enzyme activity inhibition and 2 times more effective to decrease melanin synthesis compared to C. cohnii. Considering low toxicity to B16-F10 melanoma and healthy keratinocyte cells (HaCaT), S. limacinum fatty acids could be a suitable source for lipid-based tyrosinase inhibitory functional cosmetics products.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
