Abstract
The ethanolic extract of Lentinula edodes was partially analyzed and then characterized for its efficacy in treating atopic dermatitis. Polyphenols were determined to be the major antioxidant component in the extract (6.12 mg/g), followed by flavonoids (1.76 mg/g), β-carotene (28.75 μg/g), and lycopene (5.25 μg/g). An atopic dermatitis (AD) model was established and epidermal and dermal ear thickness, mast cell infiltration, and serum immunoglobulin levels were measured after oral administration of the L. edodes extract for 4 weeks. L. edodes extract decreased Dermatophagoides farinae extract (DFE) and 4-dinitrochlorobenzene (DNCB)-induced expression of several inflammatory cytokines in the ears, cervical lymph nodes, and splenocytes. Consequently, L. edodes extract may have therapeutic potential in the treatment of AD attributable to its immunomodulatory effects.
Highlights
Wild mushrooms are highly valued as a nutritious and palatable food in many societies worldwide [1,2]
Mushrooms contain dietary fiber, peptides, lectins, phenolics, terpenes, alkaloids, vitamins, and minerals [5,6]. In addition to their nutritional value, many wild edible mushrooms have been investigated for their potential as neutraceutical agents
Lentinula edodes is the second most cultivated edible mushroom in the world, representing about 25% of worldwide mushroom production; it has been used as a food and medicine in South Korea and China for millennia
Summary
Wild mushrooms are highly valued as a nutritious and palatable food in many societies worldwide [1,2]. They contain high amounts of protein, low total fat levels, and a high proportion of polyunsaturated fatty acids, making them an excellent component of low-calorie diets [3,4]. Mushrooms contain dietary fiber, peptides, lectins, phenolics, terpenes, alkaloids, vitamins, and minerals [5,6]. In addition to their nutritional value, many wild edible mushrooms have been investigated for their potential as neutraceutical agents. Ultraviolet rays in sunlight can convert bioactive sterol constituents of
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