Abstract
Summary. Samples of pooled cervical mucus from groups of animals fed melengestrol acetate (MGA) for 14 days were taken 3 and 4 days after cessation of treatment. The mucus samples were separated into protein and glycoprotein portions and the epithelial glycoprotein was isolated. The protein fraction was examined by disc electrophoresis and the epithelial glycoprotein was characterized by chemical analysis and determination of the molecular weight. The cervical mucus of one of the treated groups yielded a glycoprotein which had a reduced sulphate content when compared with that of the controls and did not show the lowered neuraminic acid content characteristic of the glycoprotein from untreated animals at oestrus. Two other groups of MGA-treated animals which received HCG 3 days after withdrawal of the progestagen did not show these anomalies. The protein in the MGA-treated samples of mucus contained considerably larger amounts of material migrating in the transferrin region of the electrophoretogram than did comparable controls.
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