Abstract
BackgroundChemerin a novel adipokine is linked to insulin resistance and adiposity which are major characteristics of polycystic ovary syndrome (PCOS).ResultsChemerin level was found to be significantly higher in PCOS group than in control group (94.99 ± 12.52 ng/dl vs 73.41 ± 6.95 ng/dl) (P < 0.001) being the highest in obese PCO group, also chemerin positively correlated with BMI, fasting insulin, and HOMA-IR (P < 0.001), Multivariate linear regression analysis for factors affecting chemerin level in both PCO groups showed that the most important factor was fasting insulin (P = 0.042).ConclusionChemerin correlates with insulin resistance and may be involved in the pathogenesis of insulin resistance in PCOS patients.
Highlights
Chemerin a novel adipokine is linked to insulin resistance and adiposity which are major characteristics of polycystic ovary syndrome (PCOS)
Chemerin level, fasting insulin and HOMA-insulin resistance (IR) were found to be significantly higher in PCO group than control group (P < 0.001), fasting blood glucose was found to be higher in PCO group than control group (P = 0.007) (Table 2)
In the post hoc analysis, chemerin level was found to be significantly higher in obese PCO group versus lean PCO, obese control, and lean control groups (P < 0.001) (Tables 3, 4, and 5), chemerin level showed a statistically significant increase in lean PCO group versus obese control and lean control groups (P < 0.001) (Tables 6 and 7) and on correlating serum chemerin with different parameters in PCO group, we found a highly significant positive correlation between chemerin and Body mass index (BMI) (P < 0.001), fasting insulin (P < 0.001), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (P < 0.001) (Table 8)
Summary
Chemerin a novel adipokine is linked to insulin resistance and adiposity which are major characteristics of polycystic ovary syndrome (PCOS). Several studies have pinpointed insulin resistance (IR) as the fundamental link associating PCOS and obesity [1] though IR may be present in PCOS independently of obesity [2]. IR seems to be an essential pathophysiologic mechanism in the development of all metabolic aspects of PCOS [3]. Chemerin is an adipokine that can regulate glucose uptake and stimulate lipolysis via phosphorylation of some intermediates in human adipocytes which are involved in mediating lipolysis and insulin signaling pathway [4]. We aim to evaluate the level of serum chemerin in a sample of Egyptian females with polycystic ovary syndrome and its relation to insulin resistance in those patients
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