Abstract
The incidence of nonmelanoma skin cancer is rising worldwide. The major carcinogenic factor for most skin cancers is solar ultraviolet light, in particular, the chronic exposure to UVB (280–320[Formula: see text]nm). In this study, the optical characteristics of skin canceration process induced by UVB were analyzed. Optical coherence tomography (OCT) was used for monitoring the morphologic changes and compared with histological analysis. Meanwhile, the optical property, such as the attenuation coefficient ([Formula: see text]t) was systematically extracted and analyzed. In addition, characteristic textures, including energy, entropy and correlation were revealed from OCT images. Results suggest that OCT is a useful tool for monitoring the process of UVB-induced skin cancer and changes of optical property during this process.
Highlights
The skin cancer is the most common type of cancer and its incidence has been growing in an alarming rate worldwide mainly due to the destruction of the ozone layer in recent years.[1,2,3] Skin cancer can lead to severe skin injury if incompletely removed with a wide margin of normal tissue, which resulted in adverse physical and psychological consequences to the patients
Optical coherence tomography (OCT) images showed that the detectable depth of four time points was di®erent
The features of OCT images corresponded well with the histological examination at each time points, which suggests that OCT is a useful tool for identifying cutaneous cancerous changes induced by chronic UVB exposure
Summary
The skin cancer is the most common type of cancer and its incidence has been growing in an alarming rate worldwide mainly due to the destruction of the ozone layer in recent years.[1,2,3] Skin cancer can lead to severe skin injury if incompletely removed with a wide margin of normal tissue, which resulted in adverse physical and psychological consequences to the patients. The gold standard for diagnosis of cutaneous diseases is still biopsy and histopathological examination. Many well-established noninvasive optical imaging methods (e.g., optical coherence tomography (OCT),[6] multiphoton microscopy7,8) have already been applied for the
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