Abstract
Multiple sclerosis (MS) is characterized by active migration of peripheral blood (PB) leukocytes across the blood–brain barrier (BBB) into the central nervous system (CNS). Integrins, which are heterodimeric alpha/beta transmembrane proteins, facilitate this process by mediating cell–cell or cell–extracellular matrix protein interactions. Specifically, the beta1 integrin family has been associated with migration of PB lymphocytes across the BBB, as supported by the clinical efficacy of Natalizumab, a monoclonal antibody targeting the alpha4 subunit of integrin alpha4beta1.
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