Abstract
A specific receptor for tumour necrosis factor present in a purified plasma membrane preparation from the villous tissue of human placenta has been characterized. The data fit a one-class-of-sites model exhibiting a K D = 28.4 (± 0.002) n m, with 8.1 (±0. 05) × 10 11 receptors mg −1 membrane protein. These data provide evidence for the existence of a specific receptor for a major endotoxin-induced cytokine in the placenta.
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