Abstract
ABSTRACT Synthetic LH-RH was infused in 2 siblings with multiple tropic hormone deficiencies and dwarfism and another patient with monotropic deficiency of hGH. A minimal response in plasma LH levels was observed in the patients with idiopathic hypopituitarism. The other individual with isolated hGH deficiency, however, showed an abrupt increase in plasma LH level with a characteristic time-course (peak at 30 min after the injection). When LH-RH was given by intravenous drip over a period of 8 hr, followed by an injection of 200 μg of synthetic LH-RH, plasma LH in the patients with multiple deficiencies rose from a basal level of 6.9 mlU/ml to 10.8 mlU/ml (case one) and 2.5 mlU/ml to 8.3 mlU/ml (case two). The absence of a significant response after a single injection of LH-RH could be the result of chronic deprivation of LH-RH due to a hypothalamic lesion in these patients.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of clinical endocrinology and metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
