Abstract
The complete mitochondrial (mt) genome of Trichuris skrjabini has been determined in the current study and subsequently compared with closely related species by phylogenetic analysis based on concatenated datasets of mt amino acid sequences. The whole mt genome of T. skrjabini is circular and 14,011 bp in length. It consists of a total of 37 genes including 13 protein coding genes (PCGs), two ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNAs) genes, and two non-coding regions. The gene arrangement and contents were consistent with other members of the Trichuridae family including Trichuris suis, Trichuris trichiura, Trichuris ovis, and Trichuris discolor. Phylogenetic analysis based on concatenated datasets of amino acids of the 12 PCGs predicted the distinctiveness of Trichuris skrjabini as compared to other members of the Trichuridae family. Overall, our study supports the hypothesis that T. skrjabini is a distinct species. The provision of molecular data of whole mt genome of T. skrjabini delivers novel genetic markers for future studies of diagnostics, systematics, population genetics, and molecular epidemiology of T. skrjabini.
Highlights
Helminthiases, some of which are often referred as neglected tropical diseases, have accounted for devastating effects on human health
The worms were extensively washed with physiological saline and identified initially as Trichuris spp. based on the morphological characteristics and predilection site [11,25]
The mt genome of T. skrjabini was comprised of 13 protein coding genes (PCGs), 22 tRNA genes, two ribosomal RNA genes, and two non-coding sites (Table 2)
Summary
Helminthiases, some of which are often referred as neglected tropical diseases, have accounted for devastating effects on human health. Whipworms are found to be in a wide range of hosts including bovines and caprines (Trichuris ovis, Trichuris discolor), dogs (Trichuris vulpis), pigs (Trichuris suis), humans (Trichuris trichiura), and non-human primates (Trichuris spp.) [5,6,7]. Transmission of these parasites is direct or occurs through a fecal–oral route. Adult worms are developed (30–50 mm in length) from first stage larvae which are burrowed in the walls of caecum and proximal colon [8]
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