Abstract
One of the major challenges for the development of drugs containing active pharmaceuticals ingredient (API) with low solubility is to add technologies to the development process in order to increase bioavailability while ensuring stability. Thus, the main objective of this work was to apply analytical methodologies in the characterization and stability of solid dispersions of atorvastatin calcium obtained by different techniques. The calorimetric curves showed different thermal profiles for the dispersions, presenting a greater interaction of the components, the SD-PEG sd. Moreover, the thermogravimetric curves showed that the PEG conferred greater stability to the dispersions. The FTIR/Pearson correlation and PXRD data revealed neither chemical interaction nor intense amorphization in the solid dispersions, respectively. Additionally, it was concluded the thermoanalytical techniques are useful, complementary, and elucidative in the characterization of the physical–chemical nature of the solid dispersions obtained by lyophilization and spray drying, providing reliable results regarding the thermal behavior and the solubility of the samples.
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