Abstract

By UVA irradiation of an ethanol solution of psoralen and oleic acid, four main photoproducts have been isolated and characterized: two have cis,cis structure; the other two are trans,cis. The same adducts have been isolated from the photoreaction of psoralen with β-oleoyl-γstearoyl-1-α-phosphatidylcholine followed by enzymatic hydrolysis with phospholipase A 2. The four isomers stimulate protein kinase C to almost the same extent.

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