Characterization of Heat Shock Factor 1 in Response to Proteasome Inhibition Unveils a Novel Therapeutic Strategy for Multiple Myeloma Treatment

Abstract

e244 The percentage of CD3+HLA-DR+ T lymphocytes in the peripheral blood of the patients suffering from MM was 3.85 3.64% (median, 2.73%) and it was significantly statistically lower (p1⁄40.01) in comparison to the control group where an average percentage of these cells was 6.01 2.84% (median, 7.01%). The percentage of CD3+CD56+16+ NKT cells in the peripheral blood of the patients with MM was 10.93 11.02% (median, 8.59%) and it was significantly statistically lower (p1⁄40.0005) in comparison to the control group (21.15 9.08%; median, 22.8%). A positive correlation between the percentage of CD3+HLA-DR+ T lymphocytes and the percentage of BDCA2+CD123+ lymphoid DCs in bone marrow was demonstrated. The relation was statistically significant p1⁄40.001. Furthermore, a significant, positive correlation was found between the percentage of CD3+CD56+CD16+ NKT cells and the percentage of BDCA2+CD123+ lymphoid DCs in bone marrow (p1⁄40.04). Obtained results revealed the relations between the percentage of DCs subpopulations and lymphocytes subsets, especially the activated ones, in the peripheral blood and bone marrow. The previously described role of DCs in the process of an immunological response, either adaptive or innate, lets us think that the decrease of the number or percentage of these cells may have a negative influence on the process of an activation of effector cells and, consequently, on the effectiveness of a response to foreign as well as neoplastic antigens in patients suffering from MM.