Abstract
In the present study, we report the preparation of silver nanoparticles in the range of10–15 nm with increased stability and enhanced anti-bacterial potency. The morphology ofthe nanoparticles was characterized by transmission electron microscopy. The antibacterialeffect of silver nanoparticles used in this study was found to be far more potent than thatdescribed in the earlier reports. This effect was dose dependent and was morepronounced against gram-negative bacteria than gram-positive organisms. Althoughbacterial cell lysis could be one of the reasons for the observed antibacterial property,nanoparticles also modulated the phosphotyrosine profile of putative bacterial peptides,which could thus affect bacterial signal transduction and inhibit the growth of theorganisms.
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