Abstract
A novel carbon nanotubes modified electrode was fabricated, which was based on multi-walled carbon nanotubes (MWCNTs) dispersed in gold nanoparticles (AuNPs) colloid. It was observed that MWCNTs were dispersed in AuNPs colloid homogenously. Dihexadecyl hydrogen phosphate (DHP) was added into the suspension to prepare a more stable film modified electrode. The film showed net structure and had good electron-transfer function. On the composite film coated electrode, the electrochemical behavior of mefenamic acid was studied and an irreversible anodic peak was obtained, which was much larger than that on a bare glassy carbon electrode (GCE), due to the co-effect of MWCNTs and AuNPs on the electrochemical oxidation of mefenamic acid. Under the optimized conditions the anodic peak current was linear to the concentration of mefenamic acid in the range of 1.0 × 10-7 to 2.0 × 10-5 mol L-1. The detection limit was estimated to be 1.0 × 10-8 mol L-1 after 120 s preconcentration. The method was applied successfully to the determination of mefenamic acid in medicine sample.
Highlights
Mefenamic acid (i.e. N-(2, 3-Xylyl) anthranilic acid, MA) is a non-steroidal drug with anti-inflammatory, analgesic and anti-pyretic activity.[1,2,3,4,5,6,7,8,9] it is widely used in treating musculoskeletal and joint disorders such as osteoarthritis and rheumatoid arthritis
When multi-walled carbon nanotubes (MWCNTs) were dispersed in AuNPs colloid with the aid of ultrasonic agitation, a black and homogenous suspension could be obtained
It was quite stable; no precipitate was observed after storing at 4 nC for two months. This should be ascribed to the electrostatic repulsion between the citrate-capped AuNPs and the oxidized carbon nanotubes with carboxylic, carbonyl and hydroxyl groups, which made the big bundles of MWCNTs dispersed
Summary
Mefenamic acid (i.e. N-(2, 3-Xylyl) anthranilic acid, MA) is a non-steroidal drug with anti-inflammatory, analgesic and anti-pyretic activity.[1,2,3,4,5,6,7,8,9] it is widely used in treating musculoskeletal and joint disorders such as osteoarthritis and rheumatoid arthritis. Several methods have been developed for MA determination, including spectrophotometry,[1,2] fluorimetry,[3,4,5] liquid chromatography (LC),[6] and chemiluminescence (CL),[7] etc These methods are generally complicated and time-consuming. Characterization of Carbon Nanotubes-Gold Nanoparticles Composite Film Modified Electrode
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