Abstract
BellaGel SmoothFine® implant is a novel nanotextured silicone breast implant. The objective of this study was to characterize differences of BellaGel SmoothFine® surfaces with commercial available implant surfaces in terms of texture, topography, and wettability as well as the behavior of capsular contracture. The surface textures of breast implants from two different manufacturers (Hans Biomed and Motiva) were evaluated. The implants utilized in this study were BellaGel Smooth®, BellaGel Textured®, BellaGel SmoothFine® or Motiva SilkSurface®. The shell textures of these implants were characterized using a scanning electron microscopy, three dimensional confocal laser scanning microscope, and contact angle goniometer. Silicone breast implants were emplaced beneath the panniculus carnosus muscle on the dorsum of Sprague Dawley rats and observed for up to 8 weeks postoperative days. The fibrous capsules around silicone implants were explanted for histological examination. BellaGel SmoothFine® exhibits a relatively flat, with little or no depth in the texturing, 5.96 ± 0.41 μm surface roughness, and a contact angle of 103.14 ± 2.06 BellGel SmoothFine® implant resulted in significant decreases in capsule thickness (P P ® and BellaGel Textured® implant groups. Significant (P ®. Fibrous tissue formation markers (Vimentin and alpha-smooth muscle actin) were significantly reduced in BellaGel SmoothFine® surfaces versus BellaGel Smooth® surfaces (P ® groups (P ® implant is associated with less breast implant derived capsular contracture than other surfaces.
Highlights
According to a 2013 report from the American Society of Plastic Surgeons, there are more than 200,000 women in the USA who had reconstructive or cosmetic breast augmentations
BellaGel SmoothFine® exhibits a relatively flat, with little or no depth in the texturing, 5.96 ± 0.41 μm surface roughness, and a contact angle of 103.14 ± 2.06 BellGel SmoothFine® implant resulted in significant decreases in capsule thickness (P < 0.05) and collagen production (P < 0.05) at 8 weeks with respect to the BellaGel Smooth® and BellaGel Textured® implant groups
These findings suggest that the nanotextured BellaGel SmoothFine® implant is associated with less breast implant derived capsular contracture than other surfaces
Summary
According to a 2013 report from the American Society of Plastic Surgeons, there are more than 200,000 women in the USA who had reconstructive or cosmetic breast augmentations. The surface texture of the shell surrounding breast implant acts as the interface between the breast tissue and device [9] and its understanding is important in the field of implantation They can markedly alter the pathophysiology and directly influence cellular biology, body tissues, and fibrous capsule development, specially the adherence of the tissue to the breast implant and the alignment of collagen fibers [8] [10] [11]. Textured-surface implants, which can disrupt the contractile forces, were developed to minimize capsular contracture [8] Serious complications such as double capsule formation, late seroma, and anaplastic large cell lymphoma (ALCL) have been appeared for textured implants due to their aggressive texturization [14] [15]
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