Abstract
Low-pressure regions inside the skull can cause vapor contents in the cerebral spinal fluid to expand and collapse in traumatic brain injury (TBI). Using cell-laden microfibers, Nicole N. Hashemi and co-workers visually analyzed the longitudinal morphological response that astrocytes express to surrounding cavitation in vitro. Genetic analytics were conducted post-cavitation to show drastic upregulation in TBI-related genes. Astrocytes are known to be neurotoxic after cranial insult, and this study, described in article 1900014, confirms the adverse effects that cavitation has on the astrocytic phenotype.
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