Characterization and in vitro drug release properties of core–shell hydrogel prepared by gamma irradiation

Abstract

ABSTRACTA hydrogel system was prepared based on core–shell approach for the delivery of trifluoperazine. Acrylonitrile (AN) core and methacrylic acid (MAA) shell copolymer were performed using gamma irradiation. The resulted system has been characterized by FTIR, TGA, TEM, and SEM techniques. The in vitro release study showed that the maximum drug released was 6.11 mg g−1 for AN–MAA copolymer through 120 min and 22.34 mg g−1 for AN-core–MAAc shell through 240 min. The results demonstrated that AN-core–MAAc had better properties than AN–MAA copolymer which means the preparation technique highly affects the properties of the system.