Abstract
The bactericidal effect of cattle normal serum on Salmonella typhimurium 395 MRO is inhibited by highly avid rabbit anti‐LPS (lipopolysaccharide) IgG. Since the inhibitory effect was destroyed by pepsin, blocking of antigenic receptors on the bacterial surface by IgG is not the sole mechanism of inhibition. Furthermore, bactericidal activity was interrupted by high concentrations of anti‐RO serum as late as after 20 min, and the inhibition was independent of the bacterial concentration, at least over a range of 2 times 103– 2 times 108 bact./ml, which leads to the following hypothesis: Anti‐LPS IgG bound to the bacterial surface activates the complement system without causing cell death but consumption of complement factors required for the slower bactericidal activity of normal serum.
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Schedule a callMore From: Acta pathologica et microbiologica Scandinavica. Section B: Microbiology and immunology
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