Abstract
Mycobacterium tuberculosis H-37 Rv when treated with different tensides (surface-active agents) dissociates into different types showing various grades of virulence ranging from a high degree to complete absence. The different morphological and physiological properties of such mycobacterial types suggest that they derive from very radical changes and that these changes are not always predictable and regular. None of the tensides used until now in cultivation of M. tuberculosis has given us perfectly dispersed growth or suspensions suitable for precise quantitative work.
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